Inhibition of Group A Streptococcus Infection

Nina Tsao, Tien-Yau Luh, Chen-Kung Chou, Jiunn-Jong Wu, Yee-Shin Lin, Huan-Yao Lei

Masaki Shoji 1, Etsuhisa Takahashi, Dai Hatakeyama, Yuma Iwai, Yuka Morita, Riku Shirayama, Noriko Echigo, Hiroshi Kido, Shigeo Nakamura, Tadahiko Mashino, Takeshi Okutani, Takashi Kuzuhara

 Surveys of exudates of the air pouch of carboxyfullerene-treated mice revealed that survival of infiltrating neutrophils was prolonged and that the bacteria were eliminated as a result of enhanced bactericidal activity of the neutrophils. Furthermore, carboxyfullerene was able to directly inhibit in vitro growth of S. pyogenes. These data suggest that carboxyfullerene can be considered an antimicrobial agent for group A streptococcus infection.

Reduces Osteoarthritis

Water-soluble C60 fullerene prevents degeneration of articular cartilage in osteoarthritis via down-regulation of chondrocyte catabolic activity and inhibition of cartilage degeneration during disease development

Kazuo Yudoh 1, Kiyoshi Shishido, Hideki Murayama, Mitsunobu Yano, Kenji Matsubayashi, Hiroya Takada, Hiroshi Nakamura, Kayo Masuko, Tomohiro Kato, Kusuki Nishioka

The aim of this study was to examine the potential of a strong free-radical scavenger, water-soluble fullerene (C60), as a protective agent against catabolic stress-induced degeneration of articular cartilage in OA, both in vitro and in vivo.

Free-Radical Scavenger

C60 Carboxyfullerene Exerts a Protective Activity against Oxidative Stress-Induced Apoptosis in Human Peripheral Blood Mononuclear Cells

Daniela Monti, Laura Moretti

C60 carboxyfullerene is a novel buckminsterfullerene-derived compound that behaves as a free-radical scavenger. In the present report, we investigated whether this drug exerts a protective activity against oxidative stress-induced apoptosis. 

Antioxidant

Antioxidant action of sugar-pendant C60 fullerenes

Masanori Horie 1, Akiko Fukuhara, Yoshiro Saito, Yasukazu Yoshida, Hiroe Sato, Hiromi Ohi, Makoto Obata, Yuji Mikata, Shigenobu Yano, Etsuo Niki

Abstract

The action of C60 fullerene and its derivatives as a radical-scavenging antioxidant has received much attention, but their reactivity toward free radicals and antioxidant capacity have not been well elucidated yet.