Fullerol nanoparticles suppress inflammatory response and adipogenesis of vertebral bone marrow stromal cells–A potential novel treatment for intervertebral disc degeneration
Qihai Liu, PhD, Li Jin, MD, PhD, Francis H. Shen, MD, Gary Balian, PhD, and Xudong Joshua Li, MD, PhD
In conclusion, we believe that this is the first observation that fullerol, a potent antioxidant agent, suppresses IL-1 β-induced ROS and inflammatory cytokine production, inhibits the adipogenic differentiation of vBMSCs in vitro and, therefore, may prevent vertebral fatty marrow deposition and inflammatory responses during disc degeneration.