Inhibition the Allergic Response

Fullerene Nanomaterials Inhibit the Allergic Response

John J. Ryan, Henry R. Bateman, Alex Stover, Greg Gomez, Sarah K. Norton, Wei Zhao, Lawrence B. Schwartz, Robert Lenk and Christopher L. Kepley
J Immunol July 1, 2007, 179 (1) 665-672; DOI: https://doi.org/10.4049/jimmunol.179.1.665

Protein microarray demonstrated that inhibition of mediator release involves profound reductions in the activation of signaling molecules involved in mediator release and oxidative stress. Follow-up studies demonstrated that the tyrosine phosphorylation of Syk was dramatically inhibited in Ag-challenged cells first incubated with fullerenes. In addition, fullerene preincubation significantly inhibited IgE-induced elevation in cytoplasmic reactive oxygen species levels. Furthermore, fullerenes prevented the in vivo release of histamine and drop in core body temperature in vivo using a MC-dependent model of anaphylaxis. These findings identify a new biological function for fullerenes and may represent a novel way to control MC-dependent diseases including asthma, inflammatory arthritis, heart disease, and multiple sclerosis.

Protects Nerves

Carboxyfullerenes as neuroprotective agents

L L Dugan 1, D M Turetsky, C Du, D Lobner, M Wheeler, C R Almli, C K Shen, T Y Luh, D W Choi, T S Lin

Two regioisomers with C3 or D3 symmetry of water-soluble carboxylic acid C60 derivatives, containing three malonic acid groups per molecule, were synthesized and found to be equipotent free radical scavengers in solution as assessed by EPR analysis. 

Prevents UV Damage

Fullerene-C60/liposome complex: Defensive effects against UVA-induced damages in skin structure, nucleus and collagen type I/IV fibrils, and the permeability into human skin tissue

Shinya Kato 1, Hisae Aoshima, Yasukazu Saitoh, Nobuhiko Miwa

 In the present study, Lpsm-Flln was administered on the surface of three-dimensional human skin tissue model, rinsed out before each UVA-irradiation at 4 J/cm(2), and thereafter added again, followed by 19-cycle-repetition for 4 days (sum: 76 J/cm(2)). UVA-caused corneum scaling and disruption of epidermis layer were detected by scanning electron microscopy. 

Protects Nerves

Buckminsterfullerenol free radical scavengers reduce excitotoxic and apoptotic death of cultured cortical neurons

L L Dugan 1, J K Gabrielsen, S P Yu, T S Lin, D W Choi

Buckminsterfullerenols also reduced neuronal apoptosis induced by serum deprivation. These results support the idea that oxidative stress contributes to both excitotoxic and apoptotic neuronal death, and furthermore suggest that fullerenols represent a novel type of biological anti-oxidant compound.

Inhibit Viruses

Using C60 fullerenes for photodynamic inactivation of mosquito iridescent viruses

Yu Rud 1, L Buchatskyy, Yu Prylutskyy, O Marchenko, A Senenko, Ch Schütze, U Ritter

This article describes the photodynamic inactivation of mosquito iridescent virus (MIV) Aedes flavescens in the presence of water-soluble C(60) fullerenes. It has been observed that the photodynamic inactivation of MIV for about 1 h reduces the infectious titre of the virus in large wax-moth larvae Galleria mellonella to 4.5 lg ID(50)/mL. The influence of the C(60) concentration on its anti-viral activity was tested in the concentration range from 1 to 0.001 mg/mL.