Inhibition the Allergic Response

Fullerene Nanomaterials Inhibit the Allergic Response

John J. Ryan, Henry R. Bateman, Alex Stover, Greg Gomez, Sarah K. Norton, Wei Zhao, Lawrence B. Schwartz, Robert Lenk and Christopher L. Kepley
J Immunol July 1, 2007, 179 (1) 665-672; DOI:

Protein microarray demonstrated that inhibition of mediator release involves profound reductions in the activation of signaling molecules involved in mediator release and oxidative stress. Follow-up studies demonstrated that the tyrosine phosphorylation of Syk was dramatically inhibited in Ag-challenged cells first incubated with fullerenes. In addition, fullerene preincubation significantly inhibited IgE-induced elevation in cytoplasmic reactive oxygen species levels. Furthermore, fullerenes prevented the in vivo release of histamine and drop in core body temperature in vivo using a MC-dependent model of anaphylaxis. These findings identify a new biological function for fullerenes and may represent a novel way to control MC-dependent diseases including asthma, inflammatory arthritis, heart disease, and multiple sclerosis.