Improve Cognitive Function Archives

A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice

Kevin L Quick 1, Sameh S Ali, Robert Arch, Chengjie Xiong, David Wozniak, Laura L Dugan

We administered a small-molecule synthetic enzyme superoxide dismutase (SOD) mimetic to wild-type (i.e. non-transgenic, non-senescence accelerated) mice starting at middle age. Chronic treatment not only reduced age-associated oxidative stress and mitochondrial radical production, but significantly extended lifespan. Treated mice also exhibited improved performance on the Morris water maze learning and memory task. This is to our knowledge the first demonstration that an administered antioxidant with mitochondrial activity and nervous system penetration not only increases lifespan, but rescues age-related cognitive impairment in mammals. SOD mimetics with such characteristics may provide unique complements to genetic strategies to study the contribution of oxidative processes to nervous system aging.

Fullerene-based antioxidants and neurodegenerative disorders

L L. Dugan 1, E G. Lovett, K L. Quick, J Lotharius, T T. Lin, K L. O'Malley

Carboxyfullerenes demonstrated robust neuroprotection against excitotoxic, apoptotic and metabolic insults in cortical cell cultures. They were also capable of rescuing mesencephalic dopaminergic neurons from both MPP(+) and 6-hydroxydopamine-induced degeneration. Although there is limited in vivo data on these compounds to date, we have previously reported that systemic administration of the C(3) carboxyfullerene isomer delayed motor deterioration and death in a mouse model of familial amyotrophic lateral sclerosis (FALS). Ongoing studies in other animal models of CNS disease states suggest that these novel antioxidants are potential neuroprotective agents for other neurodegenerative disorders, including Parkinson’s disease.

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For anyone considering the use of C60, we recommend doing your own research and look at the carbon 60 facts.

This website provides a collection the science behind Carbon 60 in hopes of providing people a resource to learn about the potential benefits of Carbon 60.

Click Here for a informational article about Carbon 60

Wikipedia Definition

“Buckminsterfullerene is a type of fullerene with the formula C₆₀. It has a cage-like fused-ring structure (truncated icosahedron) that resembles a soccer ball, made of twenty hexagons and twelve pentagons. Each carbon atom has three bonds.

It is a black solid that dissolves in hydrocarbon solvents to produce a violet solution. The compound has received intense study, although few real world applications have been found.”
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