Inhibit Influenza A

Inhibition of Group A Streptococcus Infection by Carboxyfullerene

Nina Tsao, Tien-Yau Luh, Chen-Kung Chou, Jiunn-Jong Wu, Yee-Shin Lin, Huan-Yao Lei

The effect of a water-soluble trimalonic acid derivative of fullerene, carboxyfullerene, against Streptococcus pyogenes infection was tested. Pretreatment with carboxyfullerene was able to protect mice from S. pyogenes infection in an air pouch model. S. pyogenes-induced death and skin injury were inhibited dose dependently by carboxyfullerene.

Knock Out Viruses

Fullerene compounds knock out virus infections like HIV and HSV

Skolkovo Institute of Science and Technology

Scientists from the Skoltech Center for Energy Science and Technology and the Institute of Problems of Chemical Physics of RAS in collaboration with researchers from four other Russian and foreign research centers have discovered a new reaction that helps obtain water-soluble fullerene derivatives which effectively combat flu viruses, human immunodeficiency virus (HIV), herpes simplex virus (HSV), and cytomegalovirus (CMV).

Inhibition of Group A Streptococcus Infection

Nina Tsao, Tien-Yau Luh, Chen-Kung Chou, Jiunn-Jong Wu, Yee-Shin Lin, Huan-Yao Lei

Masaki Shoji 1, Etsuhisa Takahashi, Dai Hatakeyama, Yuma Iwai, Yuka Morita, Riku Shirayama, Noriko Echigo, Hiroshi Kido, Shigeo Nakamura, Tadahiko Mashino, Takeshi Okutani, Takashi Kuzuhara

 Surveys of exudates of the air pouch of carboxyfullerene-treated mice revealed that survival of infiltrating neutrophils was prolonged and that the bacteria were eliminated as a result of enhanced bactericidal activity of the neutrophils. Furthermore, carboxyfullerene was able to directly inhibit in vitro growth of S. pyogenes. These data suggest that carboxyfullerene can be considered an antimicrobial agent for group A streptococcus infection.