Diminish Muscle Fatigue

C 60 Fullerenes Diminish Muscle Fatigue in Rats Comparable to N-acetylcysteine or β-Alanine

Inna V Vereshchaka 1, Nataliya V Bulgakova 2, Andriy V Maznychenko 2, Olga O Gonchar 3, Yuriy I Prylutskyy 4, Uwe Ritter 5, Waldemar Moska 1, Tomasz Tomiak 1, Dmytro M Nozdrenko 4, Iryna V Mishchenko 6, Alexander I Kostyukov 2 , Olena A. Kyzyma1,4, Uwe Ritter5 , Peter Scharff5 , Tomasz Tomiak6 , Dmytro M. Nozdrenko1 , Iryna V. Mishchenko7 and Alexander I. Kostyukov2

The aim of this study is to detect the effects of C60 fullerenes, which possess pronounced antioxidant properties, in comparison with the actions of the known exogenous antioxidants N-acetylcysteine (NAC) and β-Alanine in terms of exercise tolerance and contractile property changes of the m. triceps surae (TS) during development of the muscle fatigue in rats. 

Oral C60FAS administration clearly demonstrated an action on skeletal muscle fatigue development similar to the effects of i.p. injections of the exogenous antioxidants NAC or β-Alanine. This creates opportunities to oral use of C60FAS as a potential therapeutic agent. Due to the membranotropic activity of C60 fullerenes, non-toxic C60FAS has a more pronounced effect on the prooxidant-antioxidant homeostasis of muscle tissues in rats.

Olive Oil vs. Sunflower Oil

C60 fullerene as synergistic agent in tumor-inhibitory Doxorubicin treatment

Effect of olive and sunflower seed oil on the adult skin barrier: implications for neonatal skin care

Simon G Danby 1, Tareq AlEnezi, Amani Sultan, Tina Lavender, John Chittock, Kirsty Brown, Michael J Cork

The first cohort applied six drops of olive oil to one forearm twice daily for 5 weeks. The second cohort applied six drops of olive oil to one forearm and six drops of sunflower seed oil to the other twice daily for 4 weeks. The effect of the treatments was evaluated by determining stratum corneum integrity and cohesion, intercorneocyte cohesion, moisturization, skin-surface pH, and erythema. Topical application of olive oil for 4 weeks caused a significant reduction in stratum corneum integrity and induced mild erythema in volunteers with and without a history of atopic dermatitis. Sunflower seed oil preserved stratum corneum integrity, did not cause erythema, and improved hydration in the same volunteers. In contrast to sunflower seed oil, topical treatment with olive oil significantly damages the skin barrier, and therefore has the potential to promote the development of, and exacerbate existing, atopic dermatitis. The use of olive oil for the treatment of dry skin and infant massage should therefore be discouraged. 

Prevent Muscle Fatigue

C60 fullerene as promising therapeutic agent for correcting and preventing skeletal muscle fatigue

Yurij I. Prylutskyy1 , Inna V. Vereshchaka2 , Andriy V. Maznychenko2*, Nataliya V. Bulgakova2 , Olga O. Gonchar3 , Olena A. Kyzyma1,4, Uwe Ritter5 , Peter Scharff5 , Tomasz Tomiak6 , Dmytro M. Nozdrenko1 , Iryna V. Mishchenko7 and Alexander I. Kostyukov2

Abstract
Background: Bioactive soluble carbon nanostructures, such as the C60 fullerene can bond with up to six electrons, thus serving by a powerful scavenger of reactive oxygen species similarly to many natural antioxidants, widely used
to decrease the muscle fatigue effects. The aim of the study is to define action of the pristine e C60 fullerene aqueous colloid solution (C60FAS), on the post-fatigue recovering of m. triceps surae in anaesthetized rats.
Conclusions: C60FAS leads to reduction in the recovery time of the muscle contraction force and to increase in the time of active muscle functioning before appearance of steady fatigue effects. Therefore, it is possible that C60FAS affects the prooxidant-antioxidant muscle tissue homeostasis, subsequently increasing muscle endurance

Anti-Aging

Fullerene nanomaterials potentiate hair growth

Zhiguo Zhou PhD, Robert Lenk PhD, Anthony Dellinger BS Darren MacFarland PhD Krishan Kumar PhD Stephen R.Wilson PhD Christopher L.Kepley PhD, MBA

Hair loss is a common symptom resulting from a wide range of disease processes and can lead to stress in affected individuals. The purpose of this study was to examine the effect of fullerene nanomaterials on hair growth. We used shaved mice as well as SKH-1 “bald” mice to determine if fullerene-based compounds could affect hair growth and hair follicle numbers. In shaved mice, fullerenes increase the rate of hair growth as compared with mice receiving vehicle only. 

Free Radicals

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

Alugoju Phaniendra, Dinesh Babu Jestadi, and Latha Periyasamycorresponding author

 Free radicals can adversely affect various important classes of biological molecules such as nucleic acids, lipids, and proteins, thereby altering the normal redox status leading to increased oxidative stress. The free radicals induced oxidative stress has been reported to be involved in several diseased conditions such as diabetes mellitus, neurodegenerative disorders (Parkinson’s disease-PD, Alzheimer’s disease-AD and Multiple sclerosis-MS), cardiovascular diseases (atherosclerosis and hypertension), respiratory diseases (asthma), cataract development, rheumatoid arthritis and in various cancers (colorectal, prostate, breast, lung, bladder cancers).