Olive Oil vs. Sunflower Oil

C60 fullerene as synergistic agent in tumor-inhibitory Doxorubicin treatment

Effect of olive and sunflower seed oil on the adult skin barrier: implications for neonatal skin care

Simon G Danby 1, Tareq AlEnezi, Amani Sultan, Tina Lavender, John Chittock, Kirsty Brown, Michael J Cork

The first cohort applied six drops of olive oil to one forearm twice daily for 5 weeks. The second cohort applied six drops of olive oil to one forearm and six drops of sunflower seed oil to the other twice daily for 4 weeks. The effect of the treatments was evaluated by determining stratum corneum integrity and cohesion, intercorneocyte cohesion, moisturization, skin-surface pH, and erythema. Topical application of olive oil for 4 weeks caused a significant reduction in stratum corneum integrity and induced mild erythema in volunteers with and without a history of atopic dermatitis. Sunflower seed oil preserved stratum corneum integrity, did not cause erythema, and improved hydration in the same volunteers. In contrast to sunflower seed oil, topical treatment with olive oil significantly damages the skin barrier, and therefore has the potential to promote the development of, and exacerbate existing, atopic dermatitis. The use of olive oil for the treatment of dry skin and infant massage should therefore be discouraged. 

Anti-Aging

Fullerene nanomaterials potentiate hair growth

Zhiguo Zhou PhD, Robert Lenk PhD, Anthony Dellinger BS Darren MacFarland PhD Krishan Kumar PhD Stephen R.Wilson PhD Christopher L.Kepley PhD, MBA

Hair loss is a common symptom resulting from a wide range of disease processes and can lead to stress in affected individuals. The purpose of this study was to examine the effect of fullerene nanomaterials on hair growth. We used shaved mice as well as SKH-1 “bald” mice to determine if fullerene-based compounds could affect hair growth and hair follicle numbers. In shaved mice, fullerenes increase the rate of hair growth as compared with mice receiving vehicle only. 

Anti-Aging

Fullerenes as Anti-Aging Antioxidants

Yuliana P Galvan, Igor Alperovich 1, Petr Zolotukhin, Evgenia Prazdnova, Maria Mazanko, Anna Belanova, Vladimir Chistyakov

Here we review fullerenes biological effects focusing on their antioxidant and anti-ageing action. A scope of various poisonous and healing properties reported in literature for fullerene and its derivatives is analyzed. 

Anti-Aging

C60 fullerene as synergistic agent in tumor-inhibitory Doxorubicin treatment

Svitlana Prylutska 1, Iryna Grynyuk, Olga Matyshevska, Yuriy Prylutskyy, Maxim Evstigneev, Peter Scharff, Uwe Ritter

 Dox (total dose 2.5 mg/kg) combined with C60 fullerene (total dose 25 mg/kg) in tumor-bearing animals resulted in tumor growth inhibition, prolongation of life, metastasis inhibition, and increased number of apoptotic tumor cells and was more effective than the corresponding course of Dox treatment alone. C60 fullerene demonstrated a protective effect against superoxide dismutase and glutathione peroxidase inhibition induced by Dox-dependent oxidative insult in the liver and heart.

Anti-Viral

Medicinal applications of fullerenes

Rania Bakry, Rainer M Vallant, Muhammad Najam-ul-Haq, Matthias Rainer, Zoltan Szabo, Christian W Huck, and Günther K Bonn

Compounds with antiviral activity are generally of great medical interest and different modes of pharmaceutical actions have been described. Replication of the human immunodeficiency virus (HIV) can be suppressed by several antiviral compounds, which are effective in preventing or delaying the onset of acquired immunodeficiency syndrome (AIDS). Fullerenes (C60) and their derivatives have potential antiviral activity, which has strong implications on the treatment of HIV-infection. The antiviral activity of fullerene derivatives is based on several biological properties including their unique molecular architecture and antioxidant activity.

Fullerenes have unusual redox chemistry and may be reversibly reduced by up to six electrons. These, along with the low toxicity detected so far in fullerenes, are sufficient to stimulate researchers in chemistry and in biology to unite their efforts and systematically investigate the biological properties of these fascinating molecules. A wave of research and development activities all over the world has led to large number of application-oriented patents, spanning a very broad range spectrum of potential commercial applications, including: anticancer anticancer drug delivery systems using photodynamic therapy, HIV drugs, and cosmetics to slow down the aging of human skin.