PROTECTIVE EFFECT OF FULLERENOL NANO PARTICLES ON COLON CANCER DEVELOPMENT IN DIMETHYLHYDRAZINE RAT MODEL
MARTINA PERŠE, RADE INJAC a , ALEKSANDAR DJORDJEVIC b , BORUTŠTRUKELJ a , ANTON CERAR
Colorectal cancer (CRC) is one of the most common cancers world-wide, with highest incidence rates in western countries. In recent years, much effort has been dedicated in search for natural or pharmacological preventive agents, which would block or attenuate CRC process. In search for new pharmacological agent, the effects of fullerenol C60 (OH)24 nano particles (FNP) on liver oxidative status and promotion or progression phase of colorectal carcinogenesis in dimethylhydrazine-induced rat model of CRC were investigated. Our results demonstrate that FNP effectively inhibited formation of dysplastic aberrant crypt foci, which are regarded as early histopathological lesions in the pathogenesis of CRC. FNP treatment also improved activity of antioxidant enzymes in the liver.