Anti-Aging Archives | Carbon 60 Facts

Anti-Viral

C60 fullerene against SARS-CoV-2 coronavirus: an in silico insight

Vasyl V. Hurmach, Maksim O. Platonov, Svitlana V. Prylutska, Peter Scharff, Yuriy I. Prylutskyy & Uwe Ritter

According to the fact that C₆₀ fullerene (a sphere-shaped molecule consisting of carbon) has shown inhibitory activity against various protein targets, here the analysis of the potential binding mechanism between SARS-CoV-2 proteins 3CLpro and RdRp with C₆₀ fullerene was done; it has resulted in one and two possible binding mechanisms, respectively. In the case of 3CLpro, C₆₀ fullerene interacts in the catalytic binding pocket. And for RdRp in the first model C₆₀ fullerene blocks RNA synthesis pore and in the second one it prevents binding with Nsp8 co-factor (without this complex formation, RdRp can’t perform its initial functions). Then the molecular dynamics simulation confirmed the stability of created complexes. The obtained results might be a basis for other computational studies of 3CLPro and RdRp potential inhibition ways as well as the potential usage of C₆₀ fullerene in the fight against COVID-19 disease.

Olive Oil vs. Sunflower Oil

C60 fullerene as synergistic agent in tumor-inhibitory Doxorubicin treatment

Effect of olive and sunflower seed oil on the adult skin barrier: implications for neonatal skin care

Simon G Danby 1, Tareq AlEnezi, Amani Sultan, Tina Lavender, John Chittock, Kirsty Brown, Michael J Cork

The first cohort applied six drops of olive oil to one forearm twice daily for 5 weeks. The second cohort applied six drops of olive oil to one forearm and six drops of sunflower seed oil to the other twice daily for 4 weeks. The effect of the treatments was evaluated by determining stratum corneum integrity and cohesion, intercorneocyte cohesion, moisturization, skin-surface pH, and erythema. Topical application of olive oil for 4 weeks caused a significant reduction in stratum corneum integrity and induced mild erythema in volunteers with and without a history of atopic dermatitis. Sunflower seed oil preserved stratum corneum integrity, did not cause erythema, and improved hydration in the same volunteers. In contrast to sunflower seed oil, topical treatment with olive oil significantly damages the skin barrier, and therefore has the potential to promote the development of, and exacerbate existing, atopic dermatitis. The use of olive oil for the treatment of dry skin and infant massage should therefore be discouraged.

Prevent Muscle Fatigue

C60 fullerene as promising therapeutic agent for correcting and preventing skeletal muscle fatigue

Yurij I. Prylutskyy1 , Inna V. Vereshchaka2 , Andriy V. Maznychenko2*, Nataliya V. Bulgakova2 , Olga O. Gonchar3 , Olena A. Kyzyma1,4, Uwe Ritter5 , Peter Scharff5 , Tomasz Tomiak6 , Dmytro M. Nozdrenko1 , Iryna V. Mishchenko7 and Alexander I. Kostyukov2

Abstract
Background: Bioactive soluble carbon nanostructures, such as the C60 fullerene can bond with up to six electrons, thus serving by a powerful scavenger of reactive oxygen species similarly to many natural antioxidants, widely used
to decrease the muscle fatigue effects. The aim of the study is to define action of the pristine e C60 fullerene aqueous colloid solution (C60FAS), on the post-fatigue recovering of m. triceps surae in anaesthetized rats.
Conclusions: C60FAS leads to reduction in the recovery time of the muscle contraction force and to increase in the time of active muscle functioning before appearance of steady fatigue effects. Therefore, it is possible that C60FAS affects the prooxidant-antioxidant muscle tissue homeostasis, subsequently increasing muscle endurance

Anti-Aging

Fullerene nanomaterials potentiate hair growth

Zhiguo Zhou PhD, Robert Lenk PhD, Anthony Dellinger BS Darren MacFarland PhD Krishan Kumar PhD Stephen R.Wilson PhD Christopher L.Kepley PhD, MBA

Hair loss is a common symptom resulting from a wide range of disease processes and can lead to stress in affected individuals. The purpose of this study was to examine the effect of fullerene nanomaterials on hair growth. We used shaved mice as well as SKH-1 “bald” mice to determine if fullerene-based compounds could affect hair growth and hair follicle numbers. In shaved mice, fullerenes increase the rate of hair growth as compared with mice receiving vehicle only.

Anti-Aging

Fullerenes as Anti-Aging Antioxidants

Yuliana P Galvan, Igor Alperovich 1, Petr Zolotukhin, Evgenia Prazdnova, Maria Mazanko, Anna Belanova, Vladimir Chistyakov

Here we review fullerenes biological effects focusing on their antioxidant and anti-ageing action. A scope of various poisonous and healing properties reported in literature for fullerene and its derivatives is analyzed.