Studies on anti-tumor and antimetastatic activities of fullerenol in a mouse breast cancer model

Studies on anti-tumor and antimetastatic activitiesof fullerenol in a mouse breast cancer model

Fang Jiao a,b , Ying Liu a , Ying Qu a , Wei Li a,b , Guoqiang Zhou a,b , Cuicui Ge a,b ,Yufeng Li a,b , Baoyun Sun a , Chunying Chen a

The purpose was to examine the anti-tumor and antimetastatic activities of fullerenol andtheirrelatedmechanisms.ThirtyEMT-6tumor-bearingmicewereinjectedintraperitoneallywith 0.1 ml saline or 0.1 ml saline containing fullerenol C 60 (OH) 20 (0.08 and 0.4 mg/ml) dailyfor 16 days. Using tumor tissues, we investigated imbalances in the oxidative defense sys-tem and the expression of several angiogenesis factors. C 60 (OH) 20 exhibits anti-tumor andantimetastatic activities in EMT-6 breast cancer metastasis model. Treatment withC 60 (OH)20 was found to modulate oxidative stress significantly. The expression of severalangiogenesis factors was reduced in tumor tissues after treatment with fullerenol.