Protective Effects of Fullerenol Nano Particles

PROTECTIVE EFFECT OF FULLERENOL NANO PARTICLES ON COLON CANCER DEVELOPMENT IN DIMETHYLHYDRAZINE RAT MODEL

MARTINA PERŠE, RADE INJAC a , ALEKSANDAR DJORDJEVIC b , BORUTŠTRUKELJ a , ANTON CERAR

Colorectal cancer (CRC) is one of the most common cancers world-wide, with highest incidence rates in western countries. In recent years, much effort has been dedicated in search for natural or pharmacological preventive agents, which would block or attenuate CRC process. In search for new pharmacological agent, the effects of fullerenol C60 (OH)24 nano particles (FNP) on liver oxidative status and promotion or progression phase of colorectal carcinogenesis in dimethylhydrazine-induced rat model of CRC were investigated. Our results demonstrate that FNP effectively inhibited formation of dysplastic aberrant crypt foci, which are regarded as early histopathological lesions in the pathogenesis of CRC. FNP treatment also improved activity of antioxidant enzymes in the liver.

Studies on anti-tumor and antimetastatic activities of fullerenol in a mouse breast cancer model

Studies on anti-tumor and antimetastatic activitiesof fullerenol in a mouse breast cancer model

Fang Jiao a,b , Ying Liu a , Ying Qu a , Wei Li a,b , Guoqiang Zhou a,b , Cuicui Ge a,b ,Yufeng Li a,b , Baoyun Sun a , Chunying Chen a

The purpose was to examine the anti-tumor and antimetastatic activities of fullerenol andtheirrelatedmechanisms.ThirtyEMT-6tumor-bearingmicewereinjectedintraperitoneallywith 0.1 ml saline or 0.1 ml saline containing fullerenol C 60 (OH) 20 (0.08 and 0.4 mg/ml) dailyfor 16 days. Using tumor tissues, we investigated imbalances in the oxidative defense sys-tem and the expression of several angiogenesis factors. C 60 (OH) 20 exhibits anti-tumor andantimetastatic activities in EMT-6 breast cancer metastasis model. Treatment withC 60 (OH)20 was found to modulate oxidative stress significantly. The expression of severalangiogenesis factors was reduced in tumor tissues after treatment with fullerenol.

Diminish Muscle Fatigue

C 60 Fullerenes Diminish Muscle Fatigue in Rats Comparable to N-acetylcysteine or β-Alanine

Inna V Vereshchaka 1, Nataliya V Bulgakova 2, Andriy V Maznychenko 2, Olga O Gonchar 3, Yuriy I Prylutskyy 4, Uwe Ritter 5, Waldemar Moska 1, Tomasz Tomiak 1, Dmytro M Nozdrenko 4, Iryna V Mishchenko 6, Alexander I Kostyukov 2 , Olena A. Kyzyma1,4, Uwe Ritter5 , Peter Scharff5 , Tomasz Tomiak6 , Dmytro M. Nozdrenko1 , Iryna V. Mishchenko7 and Alexander I. Kostyukov2

The aim of this study is to detect the effects of C60 fullerenes, which possess pronounced antioxidant properties, in comparison with the actions of the known exogenous antioxidants N-acetylcysteine (NAC) and β-Alanine in terms of exercise tolerance and contractile property changes of the m. triceps surae (TS) during development of the muscle fatigue in rats. 

Oral C60FAS administration clearly demonstrated an action on skeletal muscle fatigue development similar to the effects of i.p. injections of the exogenous antioxidants NAC or β-Alanine. This creates opportunities to oral use of C60FAS as a potential therapeutic agent. Due to the membranotropic activity of C60 fullerenes, non-toxic C60FAS has a more pronounced effect on the prooxidant-antioxidant homeostasis of muscle tissues in rats.