C60 fullerene as promising therapeutic agent for correcting and preventing skeletal muscle fatigue
Yurij I. Prylutskyy1 , Inna V. Vereshchaka2 , Andriy V. Maznychenko2*, Nataliya V. Bulgakova2 , Olga O. Gonchar3 , Olena A. Kyzyma1,4, Uwe Ritter5 , Peter Scharff5 , Tomasz Tomiak6 , Dmytro M. Nozdrenko1 , Iryna V. Mishchenko7 and Alexander I. Kostyukov2
Abstract
Background: Bioactive soluble carbon nanostructures, such as the C60 fullerene can bond with up to six electrons, thus serving by a powerful scavenger of reactive oxygen species similarly to many natural antioxidants, widely used
to decrease the muscle fatigue effects. The aim of the study is to define action of the pristine e C60 fullerene aqueous colloid solution (C60FAS), on the post-fatigue recovering of m. triceps surae in anaesthetized rats.
Conclusions: C60FAS leads to reduction in the recovery time of the muscle contraction force and to increase in the time of active muscle functioning before appearance of steady fatigue effects. Therefore, it is possible that C60FAS affects the prooxidant-antioxidant muscle tissue homeostasis, subsequently increasing muscle endurance