C60 fullerene as synergistic agent in tumor-inhibitory Doxorubicin treatment

Svitlana Prylutska 1, Iryna Grynyuk, Olga Matyshevska, Yuriy Prylutskyy, Maxim Evstigneev, Peter Scharff, Uwe Ritter

 Dox (total dose 2.5 mg/kg) combined with C60 fullerene (total dose 25 mg/kg) in tumor-bearing animals resulted in tumor growth inhibition, prolongation of life, metastasis inhibition, and increased number of apoptotic tumor cells and was more effective than the corresponding course of Dox treatment alone. C60 fullerene demonstrated a protective effect against superoxide dismutase and glutathione peroxidase inhibition induced by Dox-dependent oxidative insult in the liver and heart.