Water-soluble fullerene (C60) inhibits the development of arthritis in the rat model of arthritis
Kazuo Yudoh,1 Rie Karasawa,1 Kayo Masuko,2 and Tomohiro Kato2
Recently, it has been demonstrated that oxygen free radicals have an important role as a signaling messenger in the development of inflammation and osteoclastogenesis, suggesting the implication of oxygen free radicals in the pathogenesis of arthritis. The aim of this study was to examine the potential of a strong free-radical scavenger, water-soluble fullerene (C60), as a protective agent against synovitis in arthritis, both in vitro and in vivo.