Water-soluble C60 fullerene prevents degeneration of articular cartilage in osteoarthritis via down-regulation of chondrocyte catabolic activity and inhibition of cartilage degeneration during disease development
Kazuo Yudoh 1, Kiyoshi Shishido, Hideki Murayama, Mitsunobu Yano, Kenji Matsubayashi, Hiroya Takada, Hiroshi Nakamura, Kayo Masuko, Tomohiro Kato, Kusuki Nishioka
The aim of this study was to examine the potential of a strong free-radical scavenger, water-soluble fullerene (C60), as a protective agent against catabolic stress-induced degeneration of articular cartilage in OA, both in vitro and in vivo.