Inhibition of Group A Streptococcus Infection by Carboxyfullerene
Nina Tsao, Tien-Yau Luh, Chen-Kung Chou, Jiunn-Jong Wu, Yee-Shin Lin, Huan-Yao Lei
The effect of a water-soluble trimalonic acid derivative of fullerene, carboxyfullerene, against Streptococcus pyogenes infection was tested. Pretreatment with carboxyfullerene was able to protect mice from S. pyogenes infection in an air pouch model. S. pyogenes-induced death and skin injury were inhibited dose dependently by carboxyfullerene.